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The impact of lipid-lowering treatment patterns on LDL-C reduction and goal attainment in secondary prevention in Germany

Authors:

Srinivasan Rajagopalan ,

Med Data Analytics Inc., 5500 Main Street, Suite 313, Williamsville, NY 14221, US
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José Luiz Vieira,

WHO Collaborating Center for the Prevention of Pathological Aging and Associated Chronic-degenerative Diseases at Institute of Geriatrics, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, BR
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Evo Alemao,

Merck & Co. Inc., Whitehouse Station, NJ, US
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Donald Yin,

Merck & Co. Inc., Whitehouse Station, NJ, US
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Emilio H. Moriguchi

WHO Collaborating Center for the Prevention of Pathological Aging and Associated Chronic-degenerative Diseases at Institute of Geriatrics, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, BR
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Abstract

Background: Information on lipid-lowering treatment (LLT) patterns (statin titration, statin switching, combination therapy and no change) in clinical practice is limited. The objectives of this study were to (i) characterize LLT patterns, (ii) explore variables that influence choice of aggressive initial and subsequent statin regimens and (iii) evaluate the impact of LLT patterns on LDL-C reduction and goal attainment.

Design: Randomly drawn patients who were newly initiated on statin (n = 603) from 62 randomly selected practices were retrospectively evaluated for a median of 3.9 years between 1998 and 2002.

Methods: Logistic regression, Cox model, t-test and GLM were used in the analyses. All tests of statistical significance were two-sided with a = 0.05.

Results: Both patient- and physician-related variables were important in the choice of initial and subsequent statin regimens. Patients initiated on LLT after revascularization were more likely to receive a high potency statin both initially and during subsequent changes. LDL-C levels influenced the choice of aggressive regimen. Switches to an aggressive regimen (68%) occurred in the first two years of therapy. Patients with more cardiac-related prescriptions at baseline had greater prescription persistence. Despite aggressive regimen changes, relatively few patients attained the target LDL-C of 100 mg/dL; nor was the reduction significantly different from that of the non-switched group.

Conclusion: Current statinmonotherapy-dominated LLT in Germany failed to get the majority of patients to recommended LDL-C goal of <100 mg/dL. Improved lipid management strategies are required so that patients on LLT get the necessary reductions in LDL-C and the benefits of projected reductions in CVD morbidity and mortality.

How to Cite: Rajagopalan S, Vieira JL, Alemao E, Yin D, Moriguchi EH. The impact of lipid-lowering treatment patterns on LDL-C reduction and goal attainment in secondary prevention in Germany. Global Heart. 2006;2(1):15–26. DOI: http://doi.org/10.1016/j.precon.2006.06.010
Published on 01 Jan 2006.

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