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Original Research

Renal Disease is Associated with Poor Outcomes Following Isolated Coronary Artery Bypass Grafting

Authors:

Mohammed J. Alramadan,

Department of Epidemiology and Preventive Medicine, School Of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AU
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Md. Nazmul Karim,

Department of Epidemiology and Preventive Medicine, School Of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AU
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Md. Nassif Hossain,

Department of Epidemiology and Preventive Medicine, School Of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AU
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Julian A. Smith,

Department of Epidemiology and Preventive Medicine, School Of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AU
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Andrew Cochrane,

Monash Medical Centre, Monash University, Melbourne, Victoria, AU
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Christopher M. Reid,

Department of Epidemiology and Preventive Medicine, School Of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AU
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Baki Billah

Department of Epidemiology and Preventive Medicine, School Of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AU
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Abstract

Background: People with renal disease have a markedly higher risk of cardiovascular disease as well as morbidity and mortality after cardiac surgery. Little is known regarding the post-operative adverse outcomes following isolated coronary artery bypass graft (CABG) in the Australian population with renal disease.

Objectives: The aim of this study was to examine the effect of different stages of renal disease on patients’ risk of post-operative mortality and complications following isolated CABG in an Australian cohort.

Methods: Using the ANZSCTS (Australian and New Zealand Society of Cardiac and Thoracic Surgeons) registry, data from 44,968 patients who underwent isolated CABG between 2001 and 2014 were used. The effect of renal disease stages on short- and long-term outcomes were examined using multivariable logistic and Cox’s regression methods respectively.

Results: Three of 4 Australian patients (74.6%) who underwent isolated CABG had some degree of renal disease: 50.2% mild; 20.9% moderate; 2.1% severe; and 1.6% dialysis-dependent. Adjusted risk of 30-day mortality increased with deteriorating renal disease from mild (1.6-fold) to dialysis-dependent (4.6-fold). Worsening renal disease was also associated with higher risk of post-operative complications. Hazard ratio for long-term survival shows steady increase of mortality risk with worsening renal disease categories from 1.1-fold for mild to 3.9-fold for patients on dialysis.

Conclusions: Pre-existing renal disease is significantly associated with 30-day and long-term mortality, length of intensive care unit and hospital stay as well as several other post-operative complications.

Highlights

  • Of Australians who underwent isolated CABG, 74.6% had some degree of renal disease.
  • The risk of 30-day mortality after CABG increased with deteriorating renal disease.
  • Long-term survival post-CABG decreased steadily with worsening renal disease.
  • Renal disease was also associated with higher risk of post-operative complications.
How to Cite: Alramadan MJ, Karim MN, Hossain MN, Smith JA, Cochrane A, Reid CM, et al.. Renal Disease is Associated with Poor Outcomes Following Isolated Coronary Artery Bypass Grafting. Global Heart. 2019;14(4):347–53. DOI: http://doi.org/10.1016/j.gheart.2019.08.002
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Published on 01 Dec 2019.
Peer Reviewed

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