Authors:

Abstract

Background: Myocardial infarction is among the leading causes of morbidity and mortality in young adults around the world.

Objectives: In the YOUTH (Young Myocardial Infarction Study of the Western Indians) registry, we aimed to evaluate risk factor profile and angiographic outcomes of reperfusion therapies of infarct-related artery in young western Indians (≤40 years) having ST-segment elevation myocardial infarction.

Methods: A total of 1,179 consecutive patients aged ≤40 years who presented with ischemic heart disease from June 2012 to December 2014 were enrolled in the YOUTH registry. A total of 787 patients with ST-segment elevation myocardial infarction were further evaluated. Categorical data was assessed using chi-square test, whereas continuous data was assessed using Student’s t test. Regression analysis was performed to investigate the strength of association.

Results: In the YOUTH registry, the study population was predominantly male (93%) with tobacco consumption as major prevalent risk factor (49.7%). Of 787 patients, 451 (57.31%) were thrombolyzed, 326 (41.42%) did not receive any reperfusion therapy, and 10 patients (1.27%) underwent primary angioplasty. Younger age, window period n= 235) being thrombolyzed in a window period of n= 3), whereas bleeding complication was noted only in 1 patient.

Highlights

• MI has been reported to be a major cause of morbidity and mortality in young adults around the world with greater incidences in developing countries. Better understanding of the disease-related features might lead to further improvements in the management of this patient population.
• With this YOUTH registry, we aimed to evaluate risk factor profile, mode of reperfusion therapy, and angiographic assessment for patency of IRA in young western Indians having STEMI.
• We based on our findings, recommend pharmacological mode of reperfusion to achieve patency of IRA in young STEMI patients based on the observations of YOUTH registry.
• The findings of this study have clinical implications as identification of risk factors of myocardial infarction in young adults contributes significantly in its timely clinical management.