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Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology

Authors:

Álvaro Sosa-Liprandi ,

Department of Cardiovascular, Sanatorio Güemes, Buenos Aires, AR
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María Inés Sosa Liprandi,

Department of Cardiovascular, Sanatorio Güemes, Buenos Aires, AR
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Erick Alexánderson,

Department of Physiology, Faculty of Medicine, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MX
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Álvaro Avezum,

Instituto Dante Pazzanese de Cardiología, Saõ Paulo, BR
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Fernando Lanas,

Universidad de la Frontera, Temuco, CL
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José Patricio López-Jaramillo,

Clínica Fundación Oftalmologica de Santander/Clínica Carlos Ardila Lulle, Bucaramanga, CO; Eugenio Espejo Faculty of Health Sciences, Universidad Tecnológica Equinoccial, Quito, EC
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Felipe Martínez,

Instituto Médico Damic, Cordoba, AR
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Carlos I. Ponte-Negretti N,

Hospital Domingo Luciani, Caracas, Miranda State, VE
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Fernando Wyss,

Servicios y Tecnología Cardiovascular de Guatemala S.A., CARDIOSOLUTIONS, Guatemala, GT
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José Ramón González Juanatey,

Hospital Clínico Universitario de Santiago de Compostela, La Coruña, ES
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Pablo Perel

Centre for Global Chronic Conditions, London School of Hygiene and Tropical Medicine, London, GB
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Abstract

The burden of cardiovascular diseases (CVD) is increasing, particularly in low-middle-income countries such as most of Latin America. This region presents specific socioeconomic characteristics, generating a high incidence of CVD despite efforts to control the problem. A consensus statement has been developed by Inter-American Society of Cardiology with the aim of answering some important questions related to CVD in this region and the role of the polypill in cardiovascular (CV) prevention as an intervention to address these issues. A multidisciplinary team composed of Latin American experts in the prevention of CVD was convened by the Inter-American Society of Cardiology and participated in the process and the formulation of statements. To characterize the prevailing situation in Latin American countries, we describe the most significant CV risk factors in the region. The barriers that impair the use of CV essential medications are also reviewed. The role of therapeutic adherence in CV prevention and how the polypill emerges as an effective strategy for optimizing adherence, accessibility, and affordability in the treatment of CVDs are discussed in detail. Clinical scenarios in which the polypill could represent an effective intervention in primary and secondary CV prevention are described. This initiative is expected to help professionals involved in the management of CVD and public health policymakers develop optimal strategies for the management of CVDs.

Highlights

  • Latin America presents CV risk factors characteristics in part attributable to the socioeconomic status of the region.
  • Adherence represents a modifiable risk factor for new CV events. For this reason, every aspect related to adherence should be investigated individually in order to improve it.
  • Several actions could be taken in order to improve CV risk factors in Latin America, as simplifying medications regime, educational initiatives, ensuring drug accessibility and affordability, and incorporating new technologies.
  • The polypill represent a strategy that could increase adherence through improving drug accessibility, affordability, controlling risk factors. and possibly reducing CV events.
How to Cite: Sosa-Liprandi Á, Sosa Liprandi MI, Alexánderson E, Avezum Á, Lanas F, López-Jaramillo JP, et al.. Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology. Global Heart. 2019;14(1):3–16. DOI: http://doi.org/10.1016/j.gheart.2018.10.001
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Published on 01 Mar 2019.
Peer Reviewed

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