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Advances in Understanding Air Pollution and CVD

Authors:

Joel D. Kaufman ,

Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA, US
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Elizabeth W. Spalt,

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, US
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Cynthia L. Curl,

Department of Community and Environmental Health, College of Health Sciences, Boise State University, Boise, ID, US
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Anjum Hajat,

Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, US
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Miranda R. Jones,

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, US
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Sun-Young Kim,

Institute of Health and Environment, Seoul National University, Seoul, KR
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Sverre Vedal,

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, US
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Adam A. Szpiro,

Department of Biostatistics, University of Washington, Seattle, WA, US
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Amanda Gassett,

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, US
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Lianne Sheppard,

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA; Department of Biostatistics, University of Washington, Seattle, WA, US
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Martha L. Daviglus,

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, US
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Sara D. Adar

Department of Epidemiology, University of Michigan, Ann Arbor, MI, US
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Abstract

The MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution) leveraged the platform of the MESA cohort into a prospective longitudinal study of relationships between air pollution and cardiovascular health. MESA Air researchers developed fine-scale, state-of-the-art air pollution exposure models for the MESA Air communities, creating individual exposure estimates for each participant. These models combine cohort-specific exposure monitoring, existing monitoring systems, and an extensive database of geographic and meteorological information. Together with extensive phenotyping in MESA—and adding participants and health measurements to the cohort—MESA Air investigated environmental exposures on a wide range of outcomes. Advances by the MESA Air team included not only a new approach to exposure modeling, but also biostatistical advances in addressing exposure measurement error and temporal confounding. The MESA Air study advanced our understanding of the impact of air pollutants on cardiovascular disease and provided a research platform for advances in environmental epidemiology.

Highlights

  • Research advances achieved by joining modern cardiovascular epidemiology to environmental science.
  • MESA Air developed fine-scale, state-of-the-art air pollution exposure assessment.
  • MESA Air provides a research platform for advances in environmental epidemiology.
How to Cite: Kaufman JD, Spalt EW, Curl CL, Hajat A, Jones MR, Kim S-Y, et al.. Advances in Understanding Air Pollution and CVD. Global Heart. 2016;11(3):343–52. DOI: http://doi.org/10.1016/j.gheart.2016.07.004
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Published on 01 Sep 2016.
Peer Reviewed

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