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Expert Consensus Document

Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research

Authors:

Michael M. Engelgau ,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Emmanuel Peprah,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Uchechukwu K.A. Sampson,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Helena Mishoe,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Ivor J. Benjamin,

Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, US
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Pamela S. Douglas,

Duke Clinical Research Institute, Duke University, Durham, NC, US
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Judith S. Hochman,

New York University—Health and Hospitals Corporation Clinical and Translational Institute, New York University School of Medicine, New York, NY, US
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Paul M. Ridker,

Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, US
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Neal Brandes,

Implementation Research and Delivery Science Task Force, U.S. Agency for International Development, Washington, DC, US
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William Checkley,

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, US
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Sameh El-Saharty,

South Asia Region, the World Bank, Washington, DC, US
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Majid Ezzati,

Medical Research Council—Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, GB
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Anselm Hennis,

Pan American Health Organization/World Health Organization, Washington, DC, US
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Lixin Jiang,

National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, CN
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Harlan M. Krumholz,

Cardiovascular Medicine, the Robert Wood Johnson Foundation Clinical Scholars Program, University of North Carolina—Chapel Hill, Chapel Hill, NC, US
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Gabrielle Lamourelle,

Office of Global Affairs at U.S. Department of Health and Human Services, Washington, DC, US
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Julie Makani,

Nuffield Department of Clinical Medicine, University of Oxford, Oxford, GB
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K.M. Venkat Narayan,

Department of Global Health, Emory University, Atlanta, GA, US
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Kwaku Ohene-Frempong,

Comprehensive Sickle Cell Center, The Children's Hospital of Philadelphia, Philadelphia, PA, US
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Sharon E. Straus,

Internal and Geriatric Medicine, University of Toronto, Toronto, Ontario, CA
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David Stuckler,

Department of Sociology, University of Oxford, Oxford, GB
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David A. Chambers,

Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, US
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Deshirée Belis,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Glen C. Bennett,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Josephine E. Boyington,

Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Tony L. Creazzo,

Office of Scientific Review, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Janet M. de Jesus,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Chitra Krishnamurti,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Mia R. Lowden,

Office of Strategic Planning, Initiative Development, and Analysis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, US
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Antonello Punturieri,

Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Susan T. Shero,

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Neal S. Young,

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Shimian Zou,

Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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George A. Mensah

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US
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Abstract

Almost three-quarters (74%) of all the noncommunicable disease burden is found within low- and middle-income countries. In September 2014, the National Heart, Lung, and Blood Institute held a Global Health Think Tank meeting to obtain expert advice and recommendations for addressing compelling scientific questions for late stage (T4) research—research that studies implementation strategies for proven effective interventions—to inform and guide the National Heart, Lung, and Blood Institute's global health research and training efforts. Major themes emerged in two broad categories: 1) developing research capacity; and 2) efficiently defining compelling scientific questions within the local context. Compelling scientific questions included how to deliver inexpensive, scalable, and sustainable interventions using alternative health delivery models that leverage existing human capital, technologies and therapeutics, and entrepreneurial strategies. These broad themes provide perspectives that inform an overarching strategy needed to reduce the heart, lung, blood, and sleep disorders disease burden and global health disparities.

Highlights

  • In September, 2014, the National Heart, Lung, and Blood Institute (NHLBI) held a Global Health Think Tank meeting to obtain expert advice and recommendations for a global late stage (T4) translation research agenda—research that studies implementation strategies for proven effective interventions.
  • Major themes included 2 broad categories: 1) developing research capacity, and 2) efficiently defining compelling scientific questions, which included how to deliver inexpensive, scalable, and sustainable interventions within the local context.
  • These broad themes provide perspectives that inform an overarching strategy needed to reduce the heart, lung, blood, and sleep disorders disease burden and global health disparities.
How to Cite: Engelgau MM, Peprah E, Sampson UKA, Mishoe H, Benjamin IJ, Douglas PS, et al.. Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. Global Heart. 2017;12(4):341–8. DOI: http://doi.org/10.1016/j.gheart.2016.03.640
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Published on 01 Dec 2017.

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