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Multiple Risk Factor Interventions for Primary Prevention of CVD in LMIC: A Cochrane Review

Authors:

Olalekan A. Uthman ,

Warwick Centre for Applied Health Research and Delivery, Division of Health Sciences, Warwick Medical School, The University of Warwick, Warwick, GB
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Louise Hartley,

Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, GB
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Karen Rees,

Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, GB
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Fiona Taylor,

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, GB
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Shah Ebrahim,

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, GB
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Aileen Clarke

Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, GB
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Abstract

This study sought to determine the effectiveness of multiple risk factor interventions aimed at modifying major cardiovascular risk factors for the primary prevention of cardiovascular disease in low- and middle-income countries (LMIC). We searched electronic databases for randomized controlled trials of health promotion interventions to achieve behavior change. The pooled effect indicated a reduction in systolic blood pressure (–6.72 mm Hg; 95% confidence interval [CI]: –9.82 to –3.61; I2 = 91%), diastolic blood pressure (–4.40 mm Hg; 95% CI: –6.47 to –2.34; I2 = 92%), body mass index (–0.76 kg/m2; 95% CI: –1.29 to –0.22; I2 = 80%), and waist circumference (–3.31 cm; 95% CI: –4.77 to –1.86; I2 = 55%) in favor of multiple risk factor interventions. There is some evidence that multiple risk factor interventions may lower blood pressure levels and anthropometrics in populations in LMIC settings at high risk of hypertension and diabetes.

Highlights

  • The interventions may lower blood pressure, body mass index, and waist circumference.
  • No differences in measures of blood sugar and cholesterol were found.
  • None of the included trials reported on harms and deaths.
How to Cite: Uthman OA, Hartley L, Rees K, Taylor F, Ebrahim S, Clarke A. Multiple Risk Factor Interventions for Primary Prevention of CVD in LMIC: A Cochrane Review. Global Heart. 2017;12(3):199–208. DOI: http://doi.org/10.1016/j.gheart.2016.03.639
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Published on 01 Sep 2017.
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