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Review

Biomarkers of Coronary Artery Disease Differ Between Asians and Caucasians in the General Population

Authors:

Crystel M. Gijsberts ,

Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht; ICIN-Netherlands Heart Institute, Utrecht, NL
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Hester M. den Ruijter,

Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, NL
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Folkert W. Asselbergs,

Department of Cardiology, University Medical Centre Utrecht, Utrecht; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, NL; Institute of Cardiovascular Science, Population Health Sciences, University College London, London, GB
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Mark Y. Chan,

Department of Cardiology, National University Singapore; Cardiovascular Research Institute, National University Heart Centre Singapore, National University Health System, SG
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Dominique P.V. de Kleijn,

Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, NL; Cardiovascular Research Institute, National University Heart Centre Singapore, National University Health System; Department of Surgery, National University Singapore, SG
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Imo E. Hoefer

Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, NL
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Abstract

Coronary artery disease (CAD) markers have not been thoroughly investigated among Asians. The incidence of CAD, however, is rising rapidly in Asia. In this review, we systematically discuss publications that compare CAD biomarkers between Asians and Caucasians in the general population. A PubMed search yielded 5,570 hits, containing 59 articles describing 47 unique cohorts that directly compare Asians with Caucasians. Ten biomarkers were taken into account for this review: total cholesterol; triglycerides; highdensity lipoprotein cholesterol; low-density lipoprotein cholesterol; C-reactive protein; glucose; insulin; glycated hemoglobin; fibrinogen; and plasminogen activator inhibitor-1. Triglycerides were 1.13-fold higher in South Asians than in Caucasians, and insulin levels were 1.33-fold higher. In Japanese and Chinese subjects, lower C-reactive protein levels were reported: 0.52 and 0.36-fold, respectively. Ethnicityspecific prognostic measures of CAD biomarkers were rarely reported. CAD biomarker levels differ between Asians and Caucasians and among Asian ethnic groups in population-based cohorts. The ethnicity-specific prognostic value of CAD biomarkers is yet to be determined.

Highlights

  • Biomarkers for coronary artery disease differ between Asians and Caucasians.
  • Biomarkers for coronary artery disease differ among Asian ethnic groups.
  • Ethnicity-specific prognostic values of biomarkers have not been studied.
  • Ethnicity-specific prognostic values of biomarkers are needed for risk prediction.
How to Cite: Gijsberts CM, den Ruijter HM, Asselbergs FW, Chan MY, de Kleijn DPV, Hoefer IE. Biomarkers of Coronary Artery Disease Differ Between Asians and Caucasians in the General Population. Global Heart. 2015;10(4):301–11. DOI: http://doi.org/10.1016/j.gheart.2014.11.004
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Published on 01 Dec 2015.
Peer Reviewed

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