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Benzathine Penicillin G for the Management of RHD: Concerns About Quality and Access, and Opportunities for Intervention and Improvement

Authors:

Rosemary Wyber ,

Telethon Institute for Child Health Research, Perth, Western Australia, AU
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Kathryn Taubert,

World Heart Federation, Geneva, CH
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Stephen Marko,

University of Connecticut School of Medicine, Farmington, CT, US
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Edward L. Kaplan

University of Minnesota Medical School, Minneapolis, MN, US
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Abstract

Benzathine penicillin G is an important antibiotic for the treatment and prevention of group A streptococcal infections associated with rheumatic fever and rheumatic heart disease. However, as rheumatic heart disease has receded as a public health priority in most high-income settings, attention to the supply, manufacture, and accessibility of benzathine penicillin G has declined. Concerns about the quality, efficacy, and innovation of the drug have emerged following plasma analysis and anecdotal reports from low-resource settings. This review collates core issues in supply and delivery of benzathine penicillin G as a foundation for concerted efforts to improve global quality and access. Opportunities for intervention and improvement are explored.

How to Cite: Wyber R, Taubert K, Marko S, Kaplan EL. Benzathine Penicillin G for the Management of RHD: Concerns About Quality and Access, and Opportunities for Intervention and Improvement. Global Heart. 2013;8(3):227–34. DOI: http://doi.org/10.1016/j.gheart.2013.08.011
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Published on 01 Sep 2013.
Peer Reviewed

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