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Original Research

Associations of Obesity With Lipoprotein Subfractions in Japanese American, African American, and Korean Men

Authors:

Nobutaka Hirooka,

Family Medicine Faculty Development Fellowship, University of Pittsburgh, Pittsburgh, PA, US
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Chol Shin,

Department of Internal Medicine, Korea University Ansan Hospital, Ansan, KR
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Kamal H. Masaki,

Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawai`i, Mānoa, HI, US
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Daniel Edmundowicz,

Department of Medicine, Temple University, Philadelphia, PA, US
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Jina Choo,

College of Nursing, Korea University, Seoul, KR
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Emma J.M. Barinas-Mitchell,

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, US
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Bradley J. Willcox,

Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawai`i, Mānoa, HI, US
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Kim Sutton-Tyrrell,

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, US
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Aiman El-Saed,

College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, SA
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Iva Miljkovic-Gacic,

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, US
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Takayoshi Ohkubo,

Department of Health Science, Shiga University of Medical Science, Otsu, JP
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Katsuyuki Miura,

Department of Health Science, Shiga University of Medical Science, Otsu, JP
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Hirotsugu Ueshima,

Department of Health Science, Shiga University of Medical Science, Otsu, JP
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Lewis H. Kuller,

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, US
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Akira Sekikawa ,

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, US
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ERA JUMP Study Group

Abstract

Background: Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups.

Objective: This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions.

Methods: A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity—that is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index—and for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein.

Conclusions: VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R2 values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.

How to Cite: Hirooka N, Shin C, Masaki KH, Edmundowicz D, Choo J, Barinas-Mitchell EJM, et al.. Associations of Obesity With Lipoprotein Subfractions in Japanese American, African American, and Korean Men. Global Heart. 2013;8(3):273–80. DOI: http://doi.org/10.1016/j.gheart.2013.07.001
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Published on 01 Sep 2013.
Peer Reviewed

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