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Pathophysiological Mechanisms of Tobacco-Related CVD

Authors:

Salman Salahuddin,

Department of Cardiology, Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, IN
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Dorairaj Prabhakaran,

Centre for Chronic Disease Control and Director, Center of Excellence in Cardio-metabolic Risk Reduction in South Asia, Public Health Foundation of India, New Delhi, IN
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Ambuj Roy

Department of Cardiology, Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, IN
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Abstract

Cigarette smoking is a leading preventable risk factor for the development and progression of cardiovascular diseases (CVDs). Epidemiologic studies conclusively prove that both active smoking and secondhand smoke contribute significantly to morbidity and mortality related to CVD. Cigarette smoke is a mixture of several toxic chemicals, of which nicotine, carbon monoxide, and oxidant chemicals are most commonly implicated in the pathogenesis of cardiovascular disease. Tobacco causes endothelial dysfunction, inflammation, insulin resistance, alteration of lipid profile, hemodynamic alterations, and a hypercoagulable state. All of these act synergistically as pathobiologic mechanisms of atherothrombosis in tobacco users.

How to Cite: Salahuddin S, Prabhakaran D, Roy A. Pathophysiological Mechanisms of Tobacco-Related CVD. Global Heart. 2012;7(2):113–20. DOI: http://doi.org/10.1016/j.gheart.2012.05.003
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Published on 01 Jul 2012.
Peer Reviewed

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