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Reading: Autoantibodies against cardiac troponin I in patients presenting with myocarditis

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Autoantibodies against cardiac troponin I in patients presenting with myocarditis

Authors:

Akira Matsumori ,

Department of Cardiology, Tokyo Medical University, Tokyo, JP
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Toshio Shimada,

Shizuoka General Hospital, Shizuoka, JP
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Hiroaki Hattori,

Department of Advanced Medical Technology and Development, BML Inc., Saitama, JP
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Miho Shimada,

Department of Cardiology, Tokyo Medical University, Tokyo, JP
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Jay W. Mason

University of Utah, Salt Lake City, US
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Abstract

Background: Autoantibodies against cardiac troponin I (cTnI) play an important role in the pathogenesis of experimental cardiomyopathy. We developed a new method to measure anti-cardiac troponin I autoantibody (Anti-cTnIAAB) in patients with myocarditis with or without HCV infection.

Methods: Patients with heart failure for up to 2 years, without a distinct cause, were enrolled in the Myocarditis Treatment Trial between 1986 and 1990. Frozen blood samples were available from 1315 to 2233 enrolled patients. Anti-cTnIAAB was determined by a two-step immunoassay.

Results: The mean (±SEM) value of serum Anti-cTnIAAB titer in the 1315 patients was 0.067 ± 0.003 arbitrary unit (AU), significantly higher than in 1115 healthy volunteers (0.053 ± 0.002 AU, P < 0.01). The mean Anti-cTnIAAB titer in 88 patients whose endomyocardial biopsies (EMB) satisfied the diagnostic Dallas criteria was 0.086 ± 0.010 AU, versus 0.066 ± 0.004 AU in 1227 patients whose EMB did not satisfy these criteria. The mean Anti-cTnIAAB in both groups was significantly higher than that measured in the healthy volunteers (P < 0.01). The mean AnticTnIAAB titer in the 88 patients with Dallas criteria-confirmed myocarditis tended to be higher than in the other 1227 patients. Among the 88 patients with Dallas criteria-confirmed myocarditis, the mean Anti-cTnIAAB titer in 5 patients infected with the hepatitis C virus infection (HCV) was significantly higher (0.146 ± 0.047 AU) than in 83 patients without HCV infection (0.082 ± 0.010 AU, P < 0.05).

Conclusions: Elevated autoantibody titers against cTnI were detected in patients with myocarditis, and were higher in HCV-infected patients. The presence of Anti-cTnIAAB might correlate with inflammation and viral infection of the heart.

How to Cite: Matsumori A, Shimada T, Hattori H, Shimada M, Mason JW. Autoantibodies against cardiac troponin I in patients presenting with myocarditis. Global Heart. 2011;6(2):41–6. DOI: http://doi.org/10.1016/j.cvdpc.2011.02.004
Published on 01 Jun 2011.

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