Start Submission Become a Reviewer

Reading: Low HDL-cholesterol with normal triglyceride levels is the most common lipid pattern in West...

Download

A- A+
Alt. Display

Research

Low HDL-cholesterol with normal triglyceride levels is the most common lipid pattern in West Africans and African Americans with Metabolic Syndrome: Implications for cardiovascular disease prevention

Authors:

Anne E. Sumner ,

Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, US
X close

Jie Zhou,

Center For Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, US
X close

Ayo Doumatey,

Center For Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, US
X close

Omoye E. Imoisili,

Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, US
X close

Albert Amoah,

University of Ghana Medical School, Department of Medicine and Surgery, Accra, GH
X close

Joseph Acheampong,

University of Science and Technology, Department of Medicine, Kumasi, GH
X close

Johnnie Oli,

University of Nigeria Teaching Hospital, Department of Medicine, Enugu, NG
X close

Thomas Johnson,

University of Lagos, College of Medicine, Endocrine and Metabolic Unit, Lagos, NG
X close

Clement Adebamowo,

University College Hospital, Department of Surgery, Ibadan, NG
X close

Charles N. Rotimi

Center For Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, US
X close

Abstract

Background: Although designed to predict cardiovascular disease and type 2 diabetes mellitus, the Metabolic Syndrome (MetSyn) under-predicts these conditions in African Americans (AA). Failure of MetSyn in AA is often attributed to their relative absence of hypertriglyceridemia. It is unknown if the African experience with MetSyn will be similar or different to that in AA. Focusing on the lipid profile, our goal was to determine in West Africans (WA) and AA the pattern of variables that leads to the diagnosis of the MetSyn.

Methods: Cross-sectional analysis of 1296 subjects (364 WA, 44% male, 932 AA, 46% male). WA were from urban centers in Nigeria and Ghana and enrolled in the Africa America Diabetes Mellitus Study. AA lived in Washington, DC and participated in the Howard University Family Study.

Results: The prevalence of MetSyn was different in WA women and men: 42% vs.19%, P < 0.001, and in AA women and men: 25% vs.17%, P < 0.01. The three variables that most often led to the diagnosis of MetSyn in WA and AA were: low HDL-C, central obesity and hypertension. Less than 40% of AA and less than 25% of WA with the MetSyn had hypertriglyceridemia.

Conclusions: Elevated triglyceride levels were uncommon in both WA and AA with MetSyn. As the relative absence of hypertriglyceridemia is associated with a lack of efficacy of MetSyn in AA, caution is warranted in diagnosing MetSyn in WA, the ancestral population of AA. Prospective studies are necessary to determine if an ethnic-specific reformulation of the MetSyn scoring system for lipids might optimize risk identification in black populations.

How to Cite: Sumner AE, Zhou J, Doumatey A, Imoisili OE, Amoah A, Acheampong J, et al.. Low HDL-cholesterol with normal triglyceride levels is the most common lipid pattern in West Africans and African Americans with Metabolic Syndrome: Implications for cardiovascular disease prevention. Global Heart. 2010;5(3):75–80. DOI: http://doi.org/10.1016/j.cvdpc.2010.07.003
Published on 01 Sep 2010.

Downloads

  • PDF (EN)

    comments powered by Disqus