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γ-Glutamyltransferase and mortality risk from heart disease and stroke in Japanese men and women: NIPPON DATA90

Authors:

Akira Fujiyoshi ,

Department of Health Science, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192, JP
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Katsuyuki Miura,

Department of Health Science, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192, JP
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Atsushi Hozawa,

Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University School of Medicine, 2-1 Seiryomachi, Aoba-ku, Sendai 980-8575, JP
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Yoshitaka Murakami,

Department of Medical Statistics, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192, JP
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Naoyuki Takashima,

Department of Health Science, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192, JP
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Nagako Okuda,

Department of Health Science, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192; The First Institute for Health Promotion and Health Care, Japan Anti-Tuberculosis Association, 1-3-12 Suido-bashi Building, Misaki-cho, Chiyoda-ku, Tokyo 101-0061, JP
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Takashi Kadowaki,

Department of Health Science, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192, JP
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Yoshikuni Kita,

Department of Health Science, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192, JP
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Tomonori Okamura,

Department of Preventive Cardiology, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, JP
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Yasuyuki Nakamura,

Cardiovascular Epidemiology, Kyoto Women’s University, 35 Kitahiyoshi-cho, Imakumano, Higashiyama-ku, Kyoto 605-8501, JP
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Takehito Hayakawa,

Fukushima Medical University, Department of Hygiene & Preventive Medicine, 1 Hikariga-oka, Fukushima City, Fukushima Prefecture 960-1295, JP
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Akira Okayama,

The First Institute for Health Promotion and Health Care, Japan Anti-Tuberculosis Association, 1-3-12 Suido-bashi Building, Misaki-cho, Chiyoda-ku, Tokyo 101-0061, JP
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Hirotsugu Ueshima,

Department of Health Science, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192; Lifestyle-Related Disease Prevention Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192, JP
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NIPPON DATA80/90 Research Group

Abstract

Background: Studies have shown that baseline serum c-glutamyltransferase (GGT) is independently associated with cardiovascular disease (CVD) risk in men and women. However, less is known whether GGT is similarly associated with both stroke and heart disease (HD) risk in Asia. We examined an association between serum GGT and deaths from stroke and HD in Japanese men and women.

Methods: From 1990 to 2005, we followed 7488 adults (3089 men) randomly selected from 300 districts throughout Japan, aged 30–95 with no history of coronary disease nor stroke at baseline. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) according to sex-specific GGT strata.

Results: During the study period, observed deaths from HD and stroke were 165 (83 men), and 135 (66 men), respectively. After adjustment for confounding factors, HRs of HD death for 25th, 50th, 75th, and 90th GGT percentiles in reference to the lowest GGT stratum were 1.61, 2.28, 2.48, and 4.59 in women (P for trend = 0.001), and 0.90, 0.74, 1.42, and 1.56 in men (P for trend = 0.250). The corresponding HRs of total stroke death were 1.52, 0.95, 1.22, and 1.34 in women (P for trend = 0.785), and 0.75, 0.91, 1.26, and 1.02 in men (P for trend = 0.642). Results were similar when analysis was limited to never-drinkers.

Conclusion: This cohort study of representative Japanese men and women suggested that baseline GGT independently predicts future HD mortality risk, especially in women, but not stroke mortality risk in Asian.

How to Cite: Fujiyoshi A, Miura K, Hozawa A, Murakami Y, Takashima N, Okuda N, et al.. γ-Glutamyltransferase and mortality risk from heart disease and stroke in Japanese men and women: NIPPON DATA90. Global Heart. 2010;5(1):27–34. DOI: http://doi.org/10.1016/j.cvdpc.2010.03.003
Published on 01 Jan 2010.

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