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An update on cardiovascular disease epidemiology in South East Asia. Rationale and design of the LIFE course study in CARdiovascular disease Epidemiology (LIFECARE)

Authors:

E Shyong Tai ,

Center for Molecular Epidemiology, National University of Singapore, C/O Department of Community, Occupational and Family Medicine, 16 Medical Drive, Singapore 117597; Office of Research, Singapore Health Services, SG
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Richie Poulton,

Dunedin Multidisciplinary Health and Development Research Unit, Department of Preventive & Social Medicine, Dunedin School of Medicine, National Centre for Lifecourse Research, University of Otago, NZ
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Julian Thumboo,

Singapore General Hospital, Department of Rheumatology & Immunology, SG
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Rody Sy,

College of Medicine, University of the Philippines, PH
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Nina Castillo-Carandang,

Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, PH
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Piyamitr Sritara,

Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, TH
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John M.F. Adam,

Division of Endocrinology and Metabolism, Faculty of Medicine, Hsanuddin University, Makassar, ID
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Kui Hian Sim,

Clinical Research Centre (CRC), Department of Cardiology, Sarawak General Hospital; Faculty of Medicine & Health Sciences, University Malaysia Sarawak (UNIMAS), MY
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Alan Fong,

Department of Cardiology, and Clinical Research Centre, Sarawak General Hospital, MY
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Hwee Lin Wee,

Department of Pharmacy, National University of Singapore; Singapore General Hospital, Department of Rheumatology & Immunology, SG
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Mark Woodward

Mount Sinai School of Medicine, New York University, NY, US
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Abstract

The burden of cardiovascular disease (CVD) is likely to increase dramatically in Asia over the next several decades. In this paper, we review the existing data on CVD epidemiology in Asia, with a focus on the INTERHEART study and the Asia Pacific Cohort Studies Collaboration. Existing data suggests that much of CVD may be preventable through reduction in the levels of well-established CVD risk factors and that these findings are likely to be relevant to Asian populations. However, these studies have several important limitations. These include a lack of longitudinal studies with collection of repeated measures of CVD risk factors and the environmental factors that may result in the age-related increase in the levels of these risk factors. As such, the natural history of the development of CVD risk factors such as obesity, diabetes, hypertension and dyslipidemia in Asia, and their relationship in terms of duration and timing of exposure to various environmental influences is currently unknown. In addition, there is a paucity of data related to psychosocial factors that may be involved in the pathogenesis of CVD, either directly or through effects on other CVD risk factors. Finally, little data is available with regards to the impact of CVD and its attendant risk factors on health related quality of life and health care utilization. This information is crucial for the design and evaluation of evidence based programs for primary prevention. We have designed a LIFE Course Study in CARdiovascular disease Epidemiology (LIFECARE) involving 12,000 individuals in four South East Asian countries to address these data needs.
How to Cite: Tai ES, Poulton R, Thumboo J, Sy R, Castillo-Carandang N, Sritara P, et al.. An update on cardiovascular disease epidemiology in South East Asia. Rationale and design of the LIFE course study in CARdiovascular disease Epidemiology (LIFECARE). Global Heart. 2009;4(2):93–102. DOI: http://doi.org/10.1016/j.cvdpc.2009.02.003
Published on 01 Jun 2009.

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